Blonay, Lake Geneva, CH

Consulting Investors in Medical Device Development


Next Generation Touch-sensitive Ablation Catheters

The First open irrigated 3D-Force Sensitive RF-Ablation Catheter

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ATRIAL FIBRILLATION IS ONE OF THE BIGGEST THERAPEUTIC CHALLENGES 

Atrial Fibrillation (AF) is the most frequent arrhythmic disorder of the heart with a prevalence in the US of 2.3 million patients. Thromboembolic events as a consequence of AF is one main cause of stroke. 
There are two different types of AF, paroxysmal and persistent. Patients with persistent AF have a higher risk for stroke than those with paroxysmal disease .

In paroxysmal AF, pulmonary veins produce pathological action potentials that trigger variable re-entry circles (unstable Sources) in the otherwise healthy atrial myocardium. These Sources, after b
eing triggered, produce excitation at high frequencies and maintain AF for some minutes to hours before they spontaneously discontinue.

By contrast, in persistent AF the pathological mechanism is based on stable locally defined re-entry circles in a structurally changed atrial myocardium. Such structural changes may consist of fibrotic degeneration, loss of connecting gap junctions, and characteristic modifications of ion channel expression patterns. Once activated by whatever stimulus (e.g. pulmonary vein action potentials) the stable re-entry circles stay permanently active (host drivers or stable rotors) alternatively spontaneously active triggers may also frequently activate variable re-entry cycles to maintain persistent AF.

The structural changes underlying persistent AF are partially induced by long lasting AF episodes through epigenomic modifications caused by the increased levels of calcium. Therefore, an early effective Catheter Ablation treatment is recommended to stop the progress of the atrial destruction and has a clear preventive benefit together with other preventive measures like diet, sleep- and physiotherapy.


Better Visualization of AF Sources 

New Algorithm (Electrographic Mapping - EGF) alloows higher resolution AF mapping.  

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